NFL Preview, Predictions, Odds, How to Watch

Key details as Texans host 49ers
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Last update:
October 25, 2025 08:39:46 BST
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3 minutes of reading
San Francisco 49ers vs. Houston Texans Preview
Mac Jones will try to impress again when quarterback replaces Brock Purdy as the San Francisco 49ers (5-2) play another game without a long list of injured players against the Houston Texans (2-4) on Sunday.
The 49ers are tied with the Seahawks and Rams atop the NFC West and face opponents who have won two of their last 20 meetings with teams with better records, but the Texans’ defense leads the way in the NFL in points allowed per game.
“They’re really, really good,” Jones warned. “Best defense in the league, great front, great linebackers and really solid secondary.

“They have played a lot of football together and are a really talented and well-coached group. We have a huge challenge.
“They’re very strong. They have elite linebackers and guys who have seen our type of offense a lot, so they kind of know what we do and what we don’t do. We’ll definitely have our work cut out for us.”
The 49ers beat the Atlanta Falcons 20-10 at Levi’s Stadium on Monday, a day before the Texans’ two-game winning streak ended with a 27-19 loss to the Seattle Seahawks.
Prediction San Francisco 49ers @ Houston Texans
Houston also has plenty of injuries, but can be considered a slight favorite to pull off a win that already seems crucial against the backdrop of its early season struggles.
Prediction: San Francisco 49ers 18-24 Houston Texans
How to watch the San Francisco 49ers @ the Houston Texans
The game between the San Francisco 49ers and the Houston Texans will begin on Sunday at 1 p.m. ET and will be broadcast live in the United States on FOX.
San Francisco 49ers @ Houston Texans best betting offers
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