NAD + has obtained a lot of media threshing for its potential to reduce inflammation, to improve cognitive function, to reduce the risk of type 2 diabetes and to blood pressure problems and to repair the skin.
“There is a lot of interest and promises to stimulate Nad + due to the research that was carried out in animal models, but human research has not been so exciting,” said Craighead. “Many studies with people have been small and for a short time, and we are still waiting for greater studies to go out and provide final evidence.”
Research involves NAD + precursors (or molecules that the body uses to make Nad +), mainly the riboside of Nicotinamide (NR) and the nicotinamide mononucleotide (NMN), because Nad + is not very well absorbed by the body. NR and NMN, which are smaller and more easily absorbed, are converted to NAD + in cells, says Craighead.
Here are some of the potential health benefits of NAD + depending on research on pioneering supplementation of NAD + Oral so far.
Can reduce inflammation
A review theorized that the increase in NAD + levels reduces inflammatory markers (substances in the blood that increases due to inflammation), in particular interleukin-13 (IL-13). IL-13 plays a key role in regulating allergic responses and is associated with Parkinson’s disease and cancer.
“The reductions in inflammation are the most constant advantage that we see through NR studies,” says Craighead. But that the reduction in inflammation linked to NAD + is also associated with a lower chronic disease risk or prognosis has not been proven, says Craighead. “What he does in the long term, we don’t know yet.”
Can improve cognitive function for certain populations
Researchers suspect that the anti -inflammatory effects of NAD + can offer health health benefits – especially for inflammatory neurodegenerative diseases such as Parkinson’s lateral sclerosis, Alzheimer’s disease and amyotrophic (SLA). And they started investigating if there is indeed a link.
In a small study, 15 people with early Parkinson’s disease received 1,000 milligrams (MG) from NR for 30 days. This led to an average increase in NAD + levels in their brain and a decrease in inflammatory cytokines (one type of protein) compared to 15 adults with early Parkinson disease in the control group.
Researchers think that the NR can help prevent Parkinson from aggravating, but more research is needed. “There are promising profits, but the advantages are quite small and are only tested in a handful of people,” said Craighead.
And in research so far, NAD + has not been demonstrated in a conclusive manner to increase cognitive health or have protective effects for healthy individuals.
Can reduce the risk of diabetes
NAD + can reduce the risk of type 2 diabetes by improving insulin sensitivity (how your body reacts to insulin, a hormone that regulates blood sugar).
For example, a study revealed that insulin sensitivity had improved when women with prediabreaking (a condition where blood sugar is higher than healthy but not high enough for diabetes) which was overweight or had obesity completed with NMN for 10 weeks.
NAD + can operate by reducing inflammation and oxidative stress (an imbalance between harmful substances called free radicals and antioxidants that neutralize them), and by increasing the energy flow and self -shaded (a process where the cell gets rid of unnecessary or damaged components).
Craighead says research is promising, but calls for more studies with more important samples.
Can improve heart health
NAD + deficiency is associated with risk factors for heart disease, such as obesity, aging and high blood pressure (hypertension), which has led researchers to explore if the increase in NAD + levels can reduce the risk of heart disease.
Research suggests that this is the case. A meta-analysis of 29 studies has shown that the supplement with NAD + precursors has led to a significant reduction in blood pressure and inflammation in healthy people and those with various health conditions, including high cholesterol, heart disease and metabolic syndrome (a group of conditions that occur simultaneously and increase the risk of heart disease Type 2). These results have led the researchers to conclude that the precursor supplementation of NAD + can, through these mechanisms, reduce the risk of cardiovascular disease.
Craighead notes that a warning of this review is that it involved studies using niacin, which is a pioneer of Nad +, but is not commonly used, because of its undesirable side effects.
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