What is CKM syndrome? Severity, symptoms and other details about the disease affecting 90% of adult Americans
Doctors in the United States are sounding the alarm that a recently recognized health problem called cardiovascular-kidney-metabolic (CKM) syndrome now affects almost all American adults. The American Heart Association (AHA) reported in October 2025 that approximately 240 million adults have at least one health problem related to CKM, including high blood pressure, diabetes, obesity, or kidney disease.
What shocked experts was that 88% of adults surveyed said they had never heard of CKM syndrome. Health officials fear this lack of awareness could worsen the situation nationwide.
What is CKM syndrome?
CKM syndrome, short for cardiovascular-kidney-metabolic syndrome, is a medical condition describing how heart disease, kidney disease and metabolic problems like diabetes interact. The AHA officially named this disease in October 2023 to help doctors approach these diseases as a single problem rather than a separate problem.
Hospitals such as the Cleveland Clinic and Mass General Brigham describe CKM as a “full loop disorder” because a malfunction in one system can cause damage to another. This constant cycle can lead to serious decline in long-term health.
According to the AHA, damage in one area can lead to worsening conditions in all three systems, putting people at major risk of CKM.
Is CKM syndrome fatal?
CKM syndrome itself does not kill directly but increases the risk of heart attack, stroke and heart failure – the leading causes of death in the United States. Johns Hopkins Medicine found that people with diabetes are up to four times more likely to develop cardiovascular disease, one of the key findings of CKM.
The AHA warns that when multiple risk factors coexist, they multiply the levels of danger. Cardiologist Dr. Nidhi Kumar told CBS New York that CKM-related chronic diseases are now among the leading causes of death and disability across the country.
Symptoms of CKM syndrome
Symptoms of CKM vary because they develop across multiple systems. The Cleveland Clinic lists common warning signs such as:
- High blood pressure
- Abnormal cholesterol levels
- Hyperglycemia or insulin resistance
- Weight gain or obesity
- Fatigue and poor kidney function
- Swelling of the hands, feet or face
- Shortness of breath or chest pressure
Doctors classify CKM into five stages, ranging from no visible risk (stage 0) to severe, symptomatic heart disease (stage 4).
Who are the most vulnerable?
Data from the AHA and American Kidney Fund show that older adults face the greatest risk. Black Americans and people aged 20 to 44 are also at high vulnerability due to obesity and diabetes. Sedentary habits, poor diet, and family history increase the risk of developing CKM.
The AHA noted that these groups face higher rates of serious illness and require early detection to prevent complications.
Is CKM syndrome curable?
CKM syndrome cannot be cured, but it can be managed or reversed with early action. The AHA said three out of four adults could reverse CKM with medical care and lifestyle adjustments.
Recommended steps include eating balanced meals, regular exercise, and careful monitoring of blood sugar, blood pressure, and cholesterol. Dr Sanchez urged people to check their health numbers regularly as early intervention can stop further damage.
How to prevent CKM syndrome
Experts say prevention depends on healthy daily habits. Eating more vegetables, fruits and whole grains while reducing salt, sugar and processed foods helps protect vital organs. Regular physical activity and maintaining a healthy weight further reduce risks.
Doctors also emphasize routine screenings for cholesterol, blood sugar and kidney function. Avoiding smoking and limiting alcohol consumption can ease pressure on the heart and metabolism.
The AHA said most adults can control CKM with diet, exercise and medical advice – a reminder that prevention remains the most effective defense against this widespread disease.
Originally published on IBTimes UK
