What causes osteoarthritis? The 3 main factors namely

Osteoarthritis is a joint disease that causes the articular tissue to rupture over time. Although the aging and wear and tear of articles contribute to osteoarthritis, its development involves more than just natural joint wear. Although researchers do not know exactly what causes osteoarthritis, the evidence suggests that a combination of joint overuse, inflammation and genetics plays a role in its development.

The overuse of the joint, or mechanical overload, occurs when excessive or repetitive stresses damage the structures in a joint. The following elements can contribute to mechanical overload:

• Prolonged or repetitive stress: The lifting of heavy, on frequent knees or to participate in high impact sports can impact joint structures over time and increase the risk of osteoarthritis.
• Acute joint wounds: A torn ligament or damage to cartilage by a fall or a sports accident can change the alignment of the joint, creating uneven pressure that accelerates wear.
• Joint disalioning: If your joints are out of alignment, perhaps due to the flat feet, you may feel the overute joints. Disalization can lead to an unequal distribution of body weight, which means that certain areas of the joint structures wear out more quickly.
• Excess body weight: Transporting an additional body weight can express an additional constraint on carrier joints such as hips and knees, resulting in a degradation of cartilage and osteoarthritis.

Daily activities such as walking, the rise of the stairs or the race generally do not harm the healthy joints, because the cushion cartilage the ends of the bones to reduce friction during movement while ligaments and muscles ensure stability and control joint movement.

Joint inflammation is a key element of osteoarthritis. Inflammation can damage the cartilage of the joint and other structures and cause symptoms such as morning stiffness, swelling and pain. But inflammation is not only a response to joint lesions that have already occurred – it could contribute to the development of osteoarthritis in the first place.

How inflammation leads to osteoarthritis: Wounds or natural wear in the joint can trigger an inflammatory response in the body. In response to an injury or an overuse, the immune system releases inflammatory chemicals to the joint tissues to promote healing. In some cases, this immune repair process can become hyperactive, leading to chronic low level inflammation which decomposes cartilage, weakens the surrounding tissues and modifies the underlying bone structure of the joint.

Inflammation throughout the body can contribute: Inflammation associated with the development of osteoarthritis is not limited to joints; This can involve the whole body. Conditions such that obesity can trigger chronic systemic inflammation of low grade (body scale), which can make joints more prone to the development of osteoarthritis. The adipose tissue produces inflammatory substances that circulate in the blood and can contribute to joint lesions over time.

Osteoarthritis is not a hereditary condition transmitted by families. However, genetics plays a role in the development of osteoarthritis. Having a family member with osteoarthritis can increase your risk of developing the condition. Some evidence suggest that people with a parent or a brother or sister suffering from osteoarthritis can be up Three times more likely To develop the disease in relation to those who have no family history.

Genes that play a role: Researchers have identified several genes that can contribute to the risk of osteoarthritis. The mutations (changes) of the genes involved in the repair of cartilage and bone development, such as the GDF5 gene, can weaken joint structures, making them more vulnerable to wear. The variants of the genes responsible for collagen production, a cartilage protein, can harm the ability of the joint to resist mechanical stress, increasing the risk of osteoarthritis.

Arthritis is the most common form of arthritis, affecting approximately 33 million adults in the United States. Some people are more likely to develop osteoarthritis than others.

• Age: Although a person of all ages can develop osteoarthritis, the risk increases as you age. Osteoarthritis is the most frequent in people aged 45 or over.
• Sex: Osteoarthritis is much more frequent in women than men, especially after menopause.
• Ethnicity: Arthrosis affects people from all ethnic backgrounds, but is the most frequent in non -Hispanic whites. Despite lower osteoarthritis rates, research shows that blacks with osteoarthritis experience more intense pain and faster progression of the disease compared to whites.

Several factors can increase the risk of developing osteoarthritis, including the following elements:

• More advanced age: As you get older, joint tissues produce less cartilage and lose part of their ability to effectively repair damage. These age -related changes can weaken joint structures, making the elderly more vulnerable to osteoarthritis.
• Previous joint injuries: An anterior joint injury, such as a bone fracture, a ligament tear or damage to cartilage, can increase the risk of developing osteoarthritis in the affected joint. Damage to joint inflammation, chronic low grade from incorrect healing and alignment of abnormal articles can contribute to the degradation of cartilage and lead to osteoarthritis. Previous injuries are among the main causes of osteoarthritis in young adults.
• Obesity: Excess body weight is a main risk factor for osteoarthritis, especially in carrier joints such as knees and hips. It can emphasize the joints, accelerating the cartilage failure. Adipose tissue also contributes to systemic inflammation, increasing the risk of osteoarthritis.
• Lifestyle: Certain activities and professions that involve repetitive joint use or high -impact movements may increase the risk of osteoarthritis. Athletes and people who kneel or frequently raise heavy objects are more likely to develop osteoarthritis.
• Genetic: Having family history of osteoarthritis can increase your risk. Some genes that influence the cartilage structure and bone repair and cartilage mechanisms may increase the risk of osteoarthritis.
• Other joint conditions: Certain joint conditions, such as rheumatoid arthritis (RA) and gout, can increase the risk of developing osteoarthritis.

Osteoarthritis is a degenerative joint disease where joint tissues decompose over time. Although experts do not know exactly what causes osteoarthritis, the evidence suggests that a combination of joint overute, inflammation and genetics plays a role in its development.

Osteoarthritis can affect people of all ages and from all walks of life, but some groups are more at risk of osteoarthritis, including older adults, women (especially those who have gone through postmenopause) and those who have family history of the disease. Risk factors such as obesity, anterior joint injuries, repetitive labor or sports and underlying medical conditions also contribute to the probability of developing osteoarthritis.