Richarlison returns to direct the attack while Tottenham plays the action of the Champions League for the first time since 2023.
The winners of the Europa League never faced Villarreal before and with manager Thomas Frank making his own arch of the Champions League, it is the Brazil striker who begins at the front.
The new Xavi Simons signature also continues, with a new Randal Kolo Muani signature on the bench.
News from the Tottenham team
Spurs are of course always without a number of players such as Dominic Solanke, James Maddison and Dejan Kuluski.
But Frank was able to appoint a strong and attacker side. Mathys Tel, which started this weekend, is not in the Champions League team.
Tottenham XI: Vicario, 20th Sweder, System of Ven, Christian Romero, Pedro Borrow, Lucas Bergvall, Rodrigo Bentancur, Pape Matar Matar, Xavi Simons, Richarlisson, Mohammed Lives
News from the Villarreal team
Incredily, Villarreal has not yet beat an English team in the Champions League – with that their 15th attempt.
They are without Willy Kambwala, Pau Cabanes and Logan Costa by injury. The former winger of Arsenal Nicolas Pepe is starting in London again, while Captain Juan Foyth spent four years as a Spurs player before moving to Spain.
Villarreal XI: Luiz Junior, Sergi Cardona, Nenato Veiga, Juan Foyth, Santiago Mouriño, Nicolias Pépe, Pape Gueye, Sanchi Shoo
