Pittsburgh vs. Florida State Odds #25 Line: 2025 College Football Picks for Week 7 Predictions from a Proven Model

The 25th-ranked Florida State Seminoles look to end a two-game losing streak when they take on the Pittsburgh Panthers in a key Atlantic Coast Conference matchup on Saturday. Pittsburgh is coming off a 48-7 win over Boston College, while Florida State dropped a 28-22 decision to Miami last week. The Panthers (3-2, 1-1 ACC), who are tied for sixth in the conference, are 0-1 on the road this year. The Seminoles (3-2, 0-2 ACC), 16th in the championship, have a 3-1 record on their home field in 2025.
Kickoff from Doak Campbell Stadium in Tallahassee, Florida, will be at noon ET. Pittsburgh leads the all-time series 6-5. The Seminoles are 10-point favorites in the latest Pittsburgh vs. Florida State odds, while the over/under in total points scored is 57.5 via SportsLine consensus.
Before making any Pittsburgh vs. Florida State picks, be sure to check out the college football predictions and betting tips from the SportsLine Projection Model.
The model simulates each FBS game 10,000 times. Since its creation, it has generated a bet profit of well over $2,000 for $100 players on its top-rated college football picks, and is a profitable 38-25 combined on money-line and over/under picks since the start of 2024. Anyone who follows sports betting and betting apps could have seen STRONG returns!
The model has simulated Pittsburgh vs. Florida State 10,000 times and the results are in. We can tell you that the model leans below, and it also says that one side of the spread is present in more than 60% of simulations!


