The diet rich in fibers softens the symptoms of Alzheimer’s symptoms by soothing the intestinal axis, discovers the study

Nourishing animals A diet rich in fibers reduced the fragility linked to Alzheimer’s, including the tremors.

The intestine houses the largest population of immune cells in the body. A new study by Buck Institute revealed that in a mouse model Alzheimer’s Disease (AD), some of these immune cells can migrate along the brain axis, pointing to a new therapeutic strategy possible for disorder. Published in the journal Cell reportsResearch also shows that the fragility to provide mice with a diet rich in fibers has decreased the fragility linked to the MA, including tremors.

“This article means that the intestinal immune system at the forefront of the pathology of neurodegenerative diseases,” explains the associate professor of Buck Daniel Winer, MD, immunologist and co-author of the work. “Given its size and capacity of cells to travel, it is logical that these immune cells have the capacity to influence greater physiology.”

BUCK professor Julie Andersen, PHD, neuroscientist and co-ennior author adds: “As far as we know, it is the deepest study of the intestinal immune system in a model of neurodegenerative disease. We are impatient to study its impact in other diseases, in particular the sclerosis of Parkinson and in plates. ”

Migratory immune cells related to advertising

The study was led by the postdoctoral compatriot Priya Makhijani, PHD, immunologist with joint appointments in Winer and Andersen laboratories. She discovered that certain B cells producing antibodies – normally essential to maintain the balance between the microbiome and the intestinal immune system – have been reduced in genetically designed mice to develop Alzheimer’s disease (AD). A more in -depth analysis revealed that these B cells have a migratory signature. Researchers have detected specific B cells of the intestine and their migration receptors not only in the brain but also in its border region, the meningeal dura.

“Remarkably, we found that these immune cells from the brain border that recognize bacteria living in the intestines accumulated in the brain of the MA,” said Makhijani.

To explore why immune cells were exhausted from the intestine, Makhijani and his colleagues identified the role of the liaison partner of a receiver, a chemokine well known for its role in cell migration. This chemokine was produced at higher levels in glial cells, inflammatory cells of the AD brain. The team also confirmed the migratory signature in the brains of human advertising by analyzing the sets of data previously published. In collaboration with the University Health Network of the University of Toronto, they carried out blocking experiments using a drug with a small molecule, pointing towards the existence of a new long -term signaling mechanism along the axis of the intestinal brain.

The advantages of a fiber -rich diet

Makhijani and the team found that animal feed, anti-inflammatory inulin of prebiotic fiber has restored balance in the intestine of AD mice. “We have found that these migratory cells were replenished in the intestine and that the fragility linked to the AD, including the trend, has been reduced in animals.” Noting that inulin manufactures short chain fatty acids and other metabolites that are concentrated in the intestine and can also circulate systemically, it says that the diet has improved intestinal health and reduces the signaling of chemokines in the brain. “Once again, it involved a two-way axis,” she said.

Winer notes that even if the diet rich in fibers has not systematically reduced plaques levels in the brain of the mouse, this has had an impact on general well-being. “We did a test involving 31 aging measures in these mice. The diet has definitively extended their health, offering animals a better quality of life, “he said, adding:” This project supports the advice of your fruits and vegetables that appear in almost all food recommendations “.

Overview

Although the study offers a complete characterization of intestinal immune system changes in a neurological disease, researchers say that more work is necessary to see if these changes are a response to brain alterations or if they stimulate the disease itself. Winer says that the possibility is that age -related insults could trigger CD inflammation in the brain, chemokines signaling the intestinal immune system to obtain insult help. “At the beginning, the process is probably protective, but over time, the intestine becomes compromise, preparing the way for more dangerous bacteria to prosper, which feeds inflammation throughout the body.”

Makhijani is impatient to explore the potential for understanding and / or modification of the intestinal microbiome in the context of the disease. “Perhaps there is a microbiome which signals an increased risk of neurological disease. Perhaps we will be able to identify specific bacteria that have triggered inflammation of the immune system. What if we can inhibit chemokines from signaling sooner and later in the disease process?

Reference: “The amyloid-β-trained disease remodel the colonic immune system in mice” by prayer Makhijani, Tatlor R. Valentino, Max Manwaing-Mueller, Rohini Eemani, Wei-Chieh Mu, Anand Rane. Alexander Kifle, Nan Chen, Huixun du, Fei Wu, Jenny Hong Yu Ng, Benjamin D. Ambrose, Frasna Vadhana Ashok Kumaar, Khanr position, Chao Wang, Arthur Martha, David Furman, Lisa M. Anderby, Juriby, Ju Sanda S. August 29, 2025, Cell reports.
DOI: 10.1016 / J.Celrep .2025.116109

The work was funded by Nih Grant 3RF! AG062280-01S1, NIA T32 AG000266, AG066591, PO1G06659.

COO DIFULGATION: Daniel Winer is co-founder of Proprion Inc., a company that studies the interventions of immune metabolites and related to aging and related diseases.

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