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CAH treatments include drugs, psychological support and surgery. The objective is to restore the natural balance of body hormones. Some people with CAH, including men with non -classic CAH, may not need treatment.

CAH is generally treated by a doctor specializing in hormonal issues, such as an endocrinologist (or a pediatric endocrinologist in the case of children).

Medication options

The doctor can prescribe medication for a classic CAH to help balance hormones. These include:

  • Mineralocorticoids (Fludrocortisone) to replace aldosterone, which helps to counter sodium loss, prevent adrenal crises and stimulate growth and development in children
  • Glucocorticoids (Dexamethasone, Hydrocortisone, Prednisolone, Prednisone) to replace cortisol, which helps manage adrenal insufficiency, to control androgens and to manage the growth and development of childhood
  • Salt supplements (sodium chloride) to help keep salt in the body

People with CAH may have to take more glucocorticoids during stressful periods, such as when they are sick, injured or undergo surgery. These are called “doses of stress” and are given to reduce the risk of adrenal crisis. Sometimes people with non -classic CAH may also need doses of stress, for childbirth, major surgery or trauma.

A drug, Crinecerfont (crieness), was approved by the Food and Drug Administration of the United States in 2024 to treat classic CAH in people 4 years and over. The drug works by reducing pituitary stimulation to adrenal glands, thereby reducing androgen levels in the body and reducing the required dose of glucocorticoids.

Some women with non -classic CAH can also receive other treatments, including:

  • Cuglosteroids,, To help fertility or decrease the risk of miscarriage
  • Oral contraceptives,, To help regulate periods and treat acne and face hairs
  • Spironolactone (Aldactone),, To help treat acne and face hair

Surgery

Parents of girls born with ambiguous genitals can opt for surgery, especially if the genitals interfere with the ability to urinate. There is not always a “better” time to have this procedure: some parents plan surgery during the first 2 to 6 months of their child’s life. But many are encouraged to delay the decision concerning surgery and / or observation until the child is older and can be involved in the decision.

A multidisciplinary team, including a mental health supplier, a pediatric endocrinologist and a surgeon, can help you make the right decision for your child. Any surgical intervention must be carried out in a center specializing in genitoplasty.

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