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Baker Mayfield captains Buccaneers to defeat injured 49ers

October 12, 2025; Tampa, Florida, United States; Tampa Bay Buccaneers quarterback Baker Mayfield (6) rushes down the field during the second quarter against the San Francisco 49ers at Raymond James Stadium. Mandatory credit: Jonathan Dyer-Imagn Images

Baker Mayfield passed for 256 yards and two touchdowns, and Kameron Johnson and Tez Johnson each passed for their first career touchdowns to help the host Buccaneers record a 30-19 victory over the San Francisco 49ers on Sunday.

Rachaad White and Sean Tucker each rushed for a touchdown as Tampa Bay (5-1) won its second straight game. Jamel Dean and Kindle Vildor threw interceptions while helping the Buccaneers notch their largest margin of victory of the season.

Mac Jones completed 27 of 39 passes for a game-high 347 yards but was intercepted twice for the 49ers (4-2), who lost for the second time in three games. Christian McCaffrey rushed for a touchdown and had 111 yards from scrimmage (54 rushing, 57 receiving), and Kendall Bourne passed for a career-high 142 yards for the second straight game while making five catches.

San Francisco played without quarterback Brock Purdy (turf toe) for the fourth time in five games. The 49ers also lost star linebacker Fred Warner to a serious right ankle injury midway through the first quarter.

Tampa Bay was without star receiver Mike Evans (hamstring) for a third straight game and top running back Bucky Irving (foot, shoulder) for the second straight week. Standout freshman Emeka Egbuka (hamstring) missed the second half after making two catches for 24 yards in the first.

Mayfield completed 17 of 23 passes to help the Buccaneers end San Francisco’s four-game winning streak in the series.

Tampa Bay held a 27-19 lead after Tez Johnson made a stunning catch of Mayfield’s 45-yard toss with 2:40 left in the third quarter.

The 49ers drove into Buccaneers territory in the fourth quarter, but Jones’ fourth-down pass was intercepted by Dean and returned six yards to the Tampa Bay 20 with 5:43 remaining.

The Buccaneers cashed in on Chase McLaughlin’s 45-yard field goal with 1:55 left to extend the lead to 11.

White scored on a 2-yard run to give the Buccaneers a 7-0 lead. Eddy Pineiro kicked a 52-yard field goal midway through the first quarter for San Francisco, and McCaffrey scored from the 1 to give the 49ers a 10-7 lead with 10:18 left in the first half.

Tucker’s 9-yard run allowed Tampa Bay to regain the lead with 5:10 left in the half before Pineiro scored a 54-yard field goal just over three minutes later. Mayfield’s 34-yard pass to Kameron Johnson gave the Buccaneers a 20-13 lead with 44 seconds left before Pineiro made it 42 yards with two seconds left to leave San Francisco down four at the break.

Pineiro’s fourth field goal, a 29-yarder midway through the third quarter, brought the 49ers within 20-19.

–Field level media

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