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Retatrutide promises significant weight loss, but safety remains a question

There is not enough information to determine whether retatrutide is safe. The drug has not yet completed the clinical trial process and is therefore not approved by the FDA. These unknown risks could be even greater when purchasing “retatrutide” from an illicit source because it has not been regulated or evaluated by health authorities, DeCotiis says.

Preliminary research suggests that retatrutide appears to have a side effect profile quite similar to semaglutide and tirzepatide, including nausea, diarrhea, constipation, and vomiting. A handful of trial participants also experienced more serious side effects, such as increased heart rate, elevated liver enzymes and kidney problems.

Experts also worry about the possible effects of retatrutide’s very rapid weight loss. “There is concern that there is a greater risk of bone fractures,” Snyder says.

These risks may not be prohibitive for most people, and it’s very likely that retatrutide will be approved by the FDA within the next few years, DeCotiis says. But it is important to fully understand the risks of the medication before you can safely prescribe it. “We need to better understand how dosing and intervals between doses affect all of the above risks and outcomes,” says Snyder.

Experts also warn that buying compounded retatrutide from an online pharmacy that isn’t supposed to sell it in the first place could be dangerous. “If you purchase a drug through illegitimate channels, you may run into quality control issues,” says DeCotiis.

“There is no guarantee that this [the retailer says is in it] “There’s actually in there,” Davis says. “It could be contaminated.” You could also end up receiving a product with an incorrect dosage, which could pose additional health risks.

Plus, because you get it without a prescription, “there’s no medical oversight if you develop complications like serious gastrointestinal effects, pancreatitis, gallbladder problems, dehydration, or dangerous drug interactions,” Snyder says. “You assume medical, quality and legal risks without any of the safeguards built into regulated care. »

Weight loss medications should be taken under the supervision of a healthcare professional, which is not available when you buy retatrutide online without a prescription. “You have to be monitored,” DeCotiis says.

The claimed results of Retatrutide may be tempting, but experts agree that you should not buy or use the drug now. If you want to try a weight loss medication, make an appointment with your doctor to discuss FDA-approved options, like semaglutide or tirzepatide.

“I strongly advise patients to stick to FDA-approved, properly regulated prescription medications prescribed by licensed medical providers,” Snyder says. “This is the only way to ensure that you are receiving real medicine, at the right dose, under proper medical supervision.”

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