Primary sclerosing cholangitis and Crohn’s disease: what to know

“”[These include] An autoimmun mechanism, bacterial translocation, ischemia (low oxygen) in bile ducts, genetic associations and genetic mutations specifically affecting bile transport, “explains Dr Dibba. An imbalance in the intestinal microbiome can also play a role in this link.

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The PSC occurs less often in Crohn’s disease than ulcerative colitis, another form of MII, explains Muyiwa Awoniyi, MD, PHD, a transplant hepatologist at Cleveland Clinic in Ohio. About 60 to 80% of people with PSC have MIIs, but only 20% of them have Crohn.

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A journal of 61 studies revealed that less than 1% of people with Crohn had a CFP, and it was slightly more frequent in women.

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Crohn’s disease increases your risk of colorectal cancer, and if you also have PSCs, your risk increases even more, explains Dibba. As a result, you will need more frequent colonoscopies. Frequent cell renewal (development of new cells) in the gastrointestinal tract caused by intestinal damage from Crohn increases the chances of mutations that can become cancerous.

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Inflammation caused by the PSC can further increase this risk. Beyond colon cancer, it can also pave the way for biliary channel cancer and gallbladder cancer.

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