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Top 10 NFL Player Prop Bets for Week 15: Best Picks, Odds and Analysis

November 30, 2025; Pittsburgh, Pennsylvania, United States; Buffalo Bills quarterback Josh Allen (17) looks to pass as Pittsburgh Steelers defensive end Esezi Otomewo (93) attempts a tackle in the second quarter at Acrisure Stadium. Mandatory credit: Charles LeClaire-Imagn Images

We’re done with bye weeks, so there’s a full slate of games this week for our betting and watching pleasure. With division titles, playoff spots and seeding on the line, we’re bound to see the best of several of today’s biggest NFL superstars, making for some intriguing NFL player bets this week.

At the same time, we’re bound to see some of our favorite stars crumble under pressure and underperform. Either way, here are our top ten NFL player bets for Week 15 (in no special order).

Jacoby Brissett, OVER 37.5 pass attempts (+140, pari365)

The only reason I see for pricing the OVER at +140 is extreme respect for Houston’s defense. But the Cardinals are horrible at passing the ball, and they know it, which is why Brissett has attempted 40-plus passes in each of his last five games.

Jonathan Taylor, OVER 20.5 rushing attempts (-102, FanDuel)

Whether it’s Riley Leonard or Phillip Rivers at QB, the Colts need to lean heavily on Taylor for the rest of the season to have any chance of saving their season. Running backs are averaging 19.85 against Seattle’s defense, so it’s not hard to see Taylor getting MORE than 20.5 carries.

Dak Prescott, OVER 34.5 pass attempts (-125, BetMGM)

Dallas had 47 last week and averaged 40.7 over its last three. Minnesota has the No. 4 ranked pass defense, but Dallas is built to pass the ball on offense. Prescott has made more than 36 attempts in four of his last five games and 33 in the fifth.

Dallas needs to win to keep its playoff hopes alive, so they will pass early and often.

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JJ McCarty, LESS than 29.5 pass attempts (-125, bet365)

It may be tempting to go for the OVER, but McCarthy is not on the same level as Goff. Throwing it more than 30 times would put it in check. The smart play for Minnesota would be to lean on Aaron Jones and have McCarthy throw no more than 25 passes.

JJ McCarthy, throw an interception — Yes/No (-174 / +132, FanDuel)

McCarthy has had six of seven starts this season, the only exception being last week against Washington. But Dallas is tied for second-to-last in interceptions this season with five. I’m counting on the Vikings to focus on the run and take the game out of McCarthy’s hands as much as possible.

Cam Ward, OVER 32.5 pass attempts (-110, bet365)

He’s exceeded that number in three of his last four games and will likely have to make up ground for this one. They might try harder to establish the run with the way Tony Pollard ran the ball last week. But once the 49ers stop him and take a lead, Ward will throw enough to surpass that TOTAL.

Brock Purdy, LESS than 242.5 passing yards (-115, BetMGM)

Purdy has struggled to get the passing game back on track since returning from injury, throwing for 200, 193 and 168 yards over the past three weeks. Now the Titans pass defense isn’t great and they just gave up over 300 yards to Shedeur Sanders.

But I’m counting on Purdy to stay out of sync and the 49ers to focus on the run in the second half.

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Josh Allen, OVER 271.5 Passes + Rush Yards (-115, bet365)

Josh Allen, hit at any time (-110, bet365)

He had OVER 300 yards rushing earlier this season against the Patriots and has surpassed that mark in four of his last five games. If the Bills want a shot at the division title, they need to eliminate the Pats. Allen is all about making big plays this time of year and will do that here.

As for whether he will score, he didn’t score against the Pats earlier this year, but he has scored 12 times and in three of his last four games. His knack for coming out in the clutch led me to get him to score this time.

Jalen hurts, hit at any time (-120, bet365)

Hurts hasn’t been as active in the running game lately, but he has scored touchdowns in two of his last five games.

As heavy favorites in this game, at some point they will focus on the running game to kill the clock, making it a little more likely that Hurts finds his way back to the end zone.

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