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Management of side effects of androgens deprivation of deprivation

If you have received an advanced prostate cancer diagnosis, there is a good chance that you will receive an androgen deprivation (ADT) therapy at some point, because ADT is a pillar of prostate cancer treatment. It works by lowering testosterone levels, a type of androgen (a hormone) in the body that feeds the growth of prostate cancer. Hunger for fuel cancer helps reduce prostate cancer tumors and prevent news from developing.

ADT can help increase longevity for men with prostate cancer – even those with metastatic disease. But it is delivered with certain side effects, some of which can be significant, revealed that research has revealed.

“The exhaustion of testosterone creates many systemic side effects,” explains Joseph Renzulli, MD, an associate professor of urology at the Yale School of Medicine in New Haven, Connecticut. “ADT has a significant impact on men, especially those in the long term.”

Here are some common side effects from ADT, as well as advice on managing them and improving your quality of life during the treatment of prostate cancer.

1. Fatigue

A loss of testosterone can lead to fatigue, which is one of the most common side effects in ADT, explains Dr Renzulli. Fatigue is particularly common for men during the first year of therapy.

How to manage fatigue

Exercise can help increase your energy levels. Opt for resistance training, which can help increase energy levels while maintaining bone and muscle mass, explains Renzulli. Aim for about 30 minutes of exercise per day, he said.

2.

Some research has shown that people who take ADT are twice as likely to develop type 2 diabetes later as people who were not on ADT. It is not quite knowing why, but some experts believe that when testosterone decreases, body fat increases, which can cause insulin resistance.

How to manage high blood sugar

Your doctor may want to periodically monitor your blood sugar to check the diabetes. In the meantime, it is a good idea to reduce added sugars and processed foods and add more lean and plant protein to your diet. Both can contribute to healthy blood sugar.

3. High blood pressure and cholesterol

ADT can increase blood pressure and cholesterol, so your oncologist will probably work with your primary care doctor – and perhaps a cardiologist – to monitor your levels. “It should be a team approach,” says Renzulli.

How to manage high blood pressure and cholesterol

Following a healthy and healthy diet can help support healthy blood pressure and cholesterol levels. Remember to implement the Dash diet, which focuses on fruits, vegetables, whole grains, fish, poultry, beans and nuts. It also limits foods rich in salt, sugar and saturated fats.

Limiting alcohol intake to two drinks per day for men or one per day for women can also help control high blood pressure.

Take measures to remain active, which can also help stimulate heart health. Don’t you know where to start? Lace your sneakers and walk your neighborhood.

Your doctor can also make treatment recommendations to reduce your risk of cardiovascular event.

4. Weak bone

Testosterone is an androgen hormone that helps men maintain bone force. Thus, the drop in levels with ADT treatment can cause bone loss, especially when combined with bone metastases. This can increase your fracture risk. In fact, it has been believed for a long time that around 1 in 5 person with prostate cancer fractures a bone within 5 years of the start of the ADT.

How to manage weak bones

“We often encourage men … starting vitamin D and calcium supplementation [to help shore up bone health]”Explains Ramkishen Narayanan, MD, urological oncologist and director of the Center for Urologic Health at the Disney Family Cancer Center of Providence Saint Joseph Medical Center in Burbank, California.

That said, calcium and vitamin D are generally not enough to reverse bone loss. To help you, your doctor may also prescribe bone protective agents (BPAS), such as bisphosphonates, monoclonal antibodies and selective estrogen estrogen receptors, to help you create bone mineral density. A bone loss begins to occur within six months of starting the ADT, so that your doctor can prescribe BPAS shortly after starting with ADT.

5. Sexual dysfunction

Since hormone therapy reduces testosterone levels, you will probably feel a drop in sexual desire and difficulty maintaining an erection. Drugs to treat erectile dysfunction (ED) can help in some cases – but not all -. But ED drugs do not act on androgens, the deep cause of sexual dysfunction linked to ADT.

How to manage sexual dysfunction

Start by opening to your partner and incorporating them into your care. Together, you can find new ways to maintain an emotional link and a feeling of intimacy in your relationship.

Psychological treatment can help you counter a loss of Libido linked to ADT. Certain research has revealed that cognitive behavioral therapy (TCC) can help survivors of prostate cancer treated with ADT improve their sexual desire, their functioning and their satisfaction, possibly by improving the body image and the relational problems that can be ravaged.

To increase your desire, try to see a CBT specialist or practice sensible concentration therapy. The approach teaches you to focus on sensations during intimacy, rather than the pressure to perform.

Discuss side effects at each examination

Many of the side effects of the ADT disappear after the end of treatment, but some men must remain on therapy for life, explains Renzulli. In addition, some men may never find normal levels of testosterone production. It’s a good thing to help prevent prostate cancer from coming back, but you can continue to feel the effects of the ADT for years to come.

Stay in close contact with your doctors. “We strongly encourage people to maintain follow -up with the doctor prescribing the ADT to ensure that side effects are noted,” said Dr. Narayanan. “We also encourage commitment with a psychiatrist, a neurologist or a psychiatric-oncologist as part of a multidisciplinary team to ensure that emotional or cognitive problems are treated, with or without medication.”

The point to take away

  • Androgens deprivation therapy (ADT) lowers testosterone levels, a type of androgen, in the body, which helps reduce prostate cancer and prevent tumors from developing.
  • Deleting testosterone levels can also cause side effects, such as bone loss, fatigue, high blood pressure and blood sugar and sexual function problems.
  • To help reduce the side effects of ADT, try to communicate openly with your doctor on all the side effects you experience, consumption of a nutritional diet and active stay.

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