Lifestyle changes and drugs can prevent the aggravation of Mash and, in some cases, cure liver damage already occurred.
“These interventions are quite effective in stabilizing the progression of the Mash and possibly reverse the inflammation associated with the Mash,” said Dr. Karagozian.
Lifestyle changes
The changes in lifestyle are the cornerstone of management and potentially of the inversion of the Mash, whether or not a person takes medication.
Healthy food and exercise
A healthy diet and regular physical activity can help you reach a healthier weight, and this combination directly reduces the inflammation of the liver, grease accumulation and fibrosis.
You can reduce the amount of fat in your liver by losing 5 percent of your body weight, and you can cure existing scars and potentially reverse the Mash by losing 10 percent or more.
For a person of 150 pounds, a loss of 10 percent is equivalent to 15 pounds.
There is no unique diet to manage the Mash. Instead, focus on a diet rich in fruits, vegetables, whole grains, lean proteins and healthy and light fats in added sugars, red meat and whole dairy products.
Weight loss also depends on the consumption of fewer calories than you burn, so try to reduce between 500 and 1,000 calories per day.
Resist the urge to follow an intensive diet. Slow and regular weight loss is better for your liver and will also give you the opportunity to develop habits that you can use all your life.
If you have trouble losing weight thanks to a diet and exercise only, bariatric surgery or drugs can help you.
As for the exercise? Choose an activity that makes your heart beat and try to devote at least 150 minutes a week (fast walking, cycling, dance or swimming are all good choices). If the activity is vigorous (like running), you can get out of it with 75 minutes a week. Add resistance exercises twice a week to support your lean muscle mass. Ask your doctor if you start in the exercise to find the training plan that suits you.
Alcohol consumption
There is no quantity of sure drink when you drink mash. Even a moderate quantity of alcohol can worsen inflammation and accumulation of fat in the liver, which makes your liver more difficult.
Your best best? Stay away.
Drugs
Depending on the severity of your mash, your doctor can also recommend medication to help reduce the inflammation and scars of your liver.
“Most clinical trials [for these medications] Include patients with stage 2 and 3 fibrosis and show a reversal of steatohepatitis and fibrosis in certain patients, ”explains Barritt.
These drugs include:
- Resmetirom (rezdiffra) This oral medication directly reduces the amount of fat and inflammation in the liver, which can reverse the damage. It acts by linking to the beta receptor of the thyroid hormone in the liver, which regulates the metabolism of fats and inflammation of the liver. In clinical trials, up to 28 percent of patients taking resmetirom presented less liver scars in one year.
- Sumaglutide (Wegovy) The semaglutide is an injectable GLP-1 agonist often prescribed to treat diabetes and obesity. It is now also approved to treat the Mash. It is also believed that the mechanisms that support weight loss and blood sugar control contribute to reducing liver inflammation and improving scars.
Management of your blood pressure, cholesterol and blood sugar can help reduce your risk of Mash complications such as heart disease and type 2 diabetes. If you have trouble progressing only by modifying your lifestyle, your doctor can prescribe additional drugs, such as:
:max_bytes(150000):strip_icc()/GettyImages-2065537109-392996afffc84af081a91ef8b7c82064.jpg?w=390&resize=390,220&ssl=1 "Procedure, recovery, what to expect")
:max_bytes(150000):strip_icc()/GettyImages-2170864041-0cc31980183945ec9d97b931ca6fe45c.jpg?w=390&resize=390,220&ssl=1 "What magnesium can do for period cramps and discomfort")
