Health News

How long does Berberine take to lower your blood sugar?

Main to remember

  • Based on most clinical trials, the alteration effect of Berberine blood sugar was observed in about three months.
  • The results on the effect of the duration of treatment and age on the effectiveness of Berberine are contradictory.
  • Although generally well tolerated, avoid Berberine if you are pregnant, breastfeed or take certain drugs.
  • Focusing on whole foods and movements, maintaining healthy weight and avoiding it from first and used smoke is important to manage blood sugar.

The time required for Berberine to reduce blood sugar is based on the therapeutic effect observed during the duration of the treatment of clinical studies, most of which lasted three months. However, other factors, such as age, daily dose and simultaneous use of antidiabetic drugs, can affect the alteration of Berberine blood sugar.

The time it takes to lower your blood sugar

A study in people with diabetes has shown that the consumption of one gram of Berberine per day for three months reduced blood sugar by 20%.

In another three -month trial Looking at people with type 2 diabetes, the alteration effect of Berberine blood sugar was similar to that of gluCophage (metformin), a drug used to manage type 2 diabetes. While a reduction in blood sugar was observed in three months, the study periods from other trials varied from 14 days to 6 months.

Research suggests that the alteration effect of Berberine’s blood sugar lasted about three months. Berberine’s blood sugar abandonment has become remarkable with the duration of treatment over three months.

What is Berberine?

Berberine is a compound extracted from plants, such as Oregon grapes, rider and goldensal. Research has shown that Berberine improves blood sugar control and cholesterol.

How does Berberine work?

Berberine lowers the blood sugar from ::

  • Decrease in sugar production in the liver: Various signaling routes and enzymes responsible for the release of the stored sugar of the liver in the blood circulation are blocked by Berberine.
  • Decrease in insulin resistance: To make cells more sensitive to insulin, Berberine has increased the number of insulin receptors available.
  • Increase in insulin secretion: Berberine has favored insulin secretion in a dose-dependent manner. This means that Berberine only triggers insulin release when sugar is present.
  • Inhibition of several key enzymes: When the activity of an enzyme responsible for the decomposition of sugars in the intestine is blocked by Berberine, the intestinal absorption of sugar is also blocked.
  • Increase in the adoption of sugar: Berberine has increased sugar absorption by oily, muscle and hepatic cells even in the absence of insulin.

Factors that contribute to the absorbing effect of the blood sugar of Berberine

The following factors have an impact on the effect of Berberine’s blood sugar:

  • Age and severity of diabetes: There is no clear evidence that the effects of age and severity of diabetes on the effectiveness of Berberine, but research supports the use of Berberine therapy in the elderly with diabetes. However, another review suggested that the effects of Berberine on blood sugar have become commonplace in people over the age of 60. Other studies on the effect of age on the abandonment of Berberian blood sugar are necessary to clarify the results.
  • Daily dosage: Berberine’s dosage varies from 0.4 gram per day to 1.5 gram per day. However, the effects of Berberine on blood sugar were commonplace with a daily dose of more than two grams per day.
  • Concomitant use of antidiabetic drugs: The effectiveness of Berberine combined with other drugs that reduce blood sugar was better than Berberine or the anti -diabetic medication alone.
  • Duration of treatment: While a review indicated that the therapeutic effect of Berberine has become remarkable with the duration of treatment over three months, another review indicated that such an effect has become banal because the treatment lasted more than 90 days.

Tips for managing blood sugar

Some of the advice for managing blood sugar include:

  • Avoid smoking: Smoking increases heart problems and blood vessels. Even if you do not smoke, avoid being around used smoke.
  • Eat whole foods: Focus on a diet rich in vegetables, fruits, whole grains, beans, nuts and lean proteins. Drink a lot of water and limit sugary foods and drinks and highly processed foods.
  • Move more: Not only does the exercise prevents and helps managing type 2 diabetes, but it also improves your energy and your mood.
  • Look at the weight: Maintain a healthy weight to prevent or manage diabetes.
Very well health uses only high -quality sources, including studies evaluated by peers, to support the facts within our articles. Read our editorial process to find out more about how we check the facts and keep our content precise, reliable and trustworthy.
  1. Wang J, Bi C, XI H, Wei F. Effects of Berberine administration alone or in combination of type 2 diabetes mellitus: a systematic review and a meta-analysis. Pharmacol before. 2024; 15: 1455534. Published on 2024 November 21. DOI: 10.3389 / FPHAR.2024.1455534V

  2. Liang Y, Xu X, Yin M, et al. Effects of Berberine on blood sugar in patients with type 2 diabetes mellitus: a review of the systematic literature and a meta-analysis. Endocr J. 2019; 66 (1): 51-63. DOI: 10.1507 / Endocrj.ej18-0109

  3. Ye y, liu x, wu n, et al. Efficiency and safety of Berberine alone for several metabolic disorders: a systematic review and a meta-analysis of randomized clinical trials. Pharmacol before. 2021; 12: 653887. Published on 2021 April 26. DOI: 10.3389 / FPHAR.2021.653887

  4. XU X, Yi H, Wu J, et al. Therapeutic effect of Berberine on metabolic diseases: pharmacological data and clinical evidence. Biomedan pharmacother. 2021; 133: 110984. DOI: 10.1016/J.Biopha .2020.110984

  5. Utami ar, maksum IP, Deawati Y. Berberine and its study as an antidiabetic compound. Biology (Basel). 2023; 12 (7): 973. Published 2023 Jul 8 DOI: 10.3390 / Biology12070973

  6. Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and Berberine, two versatile drugs in the treatment of common metabolic diseases. Oncotarget. 2017; 9 (11): 10135-10146. Posted on September 11, 2017. DOI: 10.18632 / Oncotarget. 20807

  7. Xie W, Su F, Wang G, et al. Hypotic effect of Berberine on type 2 diabetes: a systematic review and a meta-analysis. Pharmacol before. 2022; 13: 10,15045. Published 2022 November 16. DOI: 10.3389 / FPHAR.2022.1015045

  8. Cicero AF, Baggioni A. Berberine and his role in chronic diseases. ADV Expo Biol. 2016; 928: 27-45. DOI: 10.1007 / 978-3-319-41334-1_2

  9. American Heart Association. Life’s Essential 8 – How to manage blood sugar.


By trang Tran, pharmd

Tran is a doctor in pharmacy and an independent writer in integrative health and well-being based in Oregon.

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button