Scientists have developed a test to identify women with an increased risk of miscarriage, which could open the way for new treatments to prevent loss of pregnancy.
About one of the pregnancies in six is lost, most of them before 12 weeks, and each miscarriage increases the risk of another.
Until now, most of the research in this area has focused on the quality of the embryo, with the secrets of the factory lining remaining a missing “black box” in reproductive medicine.
Now, the biggest study of gender has discovered how an abnormal process in the user lining could explain why some women make a miscarriage. The results could open the door to new ways to help women avoid loss of pregnancy.
Scientists at the University of Warwick and Coventry and Warwickshire NHS Trust university hospitals discovered that in some women with miscarriage of miscarriage, the factory lining does not react as it should and becomes a favorable place for an embryo to set up.
This represents “a key room of the miscarriage puzzle,” they said, tracing the risk of miscarriage to a problem with the uterus lining before pregnancy, which can also help explain why some women are undergoing a repeated loss of pregnancy, even with healthy embryos.
Using the study results, the team has developed a diagnostic test that can measure signs of a healthy or defective reaction in the factory lining.
The principal of the study, Dr. Joanne Mute, researcher at Warwick Medical School whose work was funded by the Baby Loss charity, Tommy’s, “said:” It is a question of identifying the avoidable miscarriages. Many women are informed that they have just had bad luck ”, but our results show that the uterus itself can prepare the ground for loss of pregnancy, even before design. “
The team analyzed around 1,500 biopsies of more than 1,300 women. They found that an essential biological process called a decide reaction, which prepares the mucous membrane for pregnancy, often does not work properly in women with a history of miscarriage.
When it is not active completely, an unstable environment is created that, while allowing implantation embryos, increases the risk of bleeding and loss of early pregnancy, the researchers revealed.
Above all, it was not random. The abnormal response in the mucosa of the uterus reproduces through menstrual cycles for certain women at a rhythm much higher than chance. This suggests a coherent, measurable and potentially preventable cause for miscarriage of miscarriage, the researchers said.
On the back of the research, the team has developed a diagnostic test to measure the molecular signals of a healthy or dysfunctional decide. The test was controlled in Coventry, England, and has already supported the care of more than 1,000 patients.
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One of the women offered the new test, Holly Milikouris, said experience was “lifeclanging” after having known five false layers.
“We felt lost and let’s start accepting that I could never have succeeded in pregnancy,” she said. “Treatments that can usually help women who have known false layers had not worked for us and whenever we were trying again, we felt like we are doing dice with the baby’s life.”
The test revealed that its factory lining was not bad for pregnancy. After treatment, she and her husband, Chris, had two healthy children, George, now three years old and Heidi, 17 months.
“Having the opportunity to participate in this test was life.
Dr. Jyotsna Vohra, director of research at Tommy, said that women undergoing the trauma and devastation of recurring miscarriages were far too often “left unanswered”. The test could, she said, “pave the way not only for an explanation in certain cases, but especially for the treatments that could prevent future loss of pregnancy”.
