The world of dental thread undergoes some radical technological progress. It seems that medical researchers around the world simultaneously discover that one of the most effective ways to reach the rest of the body is through gum.
I recently wrote on a new experimental type of dental wire that can determine stress levels. Today, in a bizarre touch to this idea, scientists have found how to transform the dental thread into a flu vaccine delivery system.
In a new study published in Biomedical engineering of natureThe researchers revealed that they could trigger immune responses in mice by coating the protein wire and an inactive flu virus, then blurring it between their tiny teeth. Finally, a product that unites the worlds of anti-flosters and anti-vacuums.
Floss dental as influenza vaccine? It could happen soon.
Vaccines generally find it difficult to work in the mouth because it is a hostile environment for foreign substances. But a nanomedicine researcher from the North Carolina State University named Harvinder Gill had a moment Eureka by reading on gum disease.
It turns out that the small trench between your teeth, the Sulcus Gingival, is unusually good for absorbing molecules. Gill figured, hey, why not slide vaccines in there? In this way, people like me, who are terrified by needles and are only moderately bored by dental silk, can be vaccinated while removing the crasals between my teeth. Win-win.
Gill and his colleague Rohan Ingrole did what no sensible person had ever tried before: they treated a mouse. The procedure involved an open person’s mouth of the rodent with a trousseau ring while the other has dental silk with gums with vaccine wire.
It seems absurd, because it is absolutely the case. Science is both ridiculous and miraculous, in an effective, earth-up and non-confessional way. The method was crazy, and I would have paid money for having seen it in person, but it worked.
About 75% of proteins on dental silk made the mouse gum fabric, and two months later, their immune systems worked at full capacity. The antibodies appeared not only in saliva, but in the lungs, the excrement, the spleen and even the bone marrow.
They release the experiences, but more: 50 mice were dental silk with an inactive influenza virus. After three dental silk sessions, the researchers exposed them to the real flu virus to see how their vaccinated mouse bodies would manage it. Each vaccinated mouse has survived. The non -vaccinated did not do so. Tear unvaccinated mouse.
To get a general idea of knowing if the method can work in humans, researchers have used dental picking covered with food dye. About 60% of the dye was absorbed by the gums of the 27 participants. Most have said they prefer dental silk to a needle, so the idea of a vaccine based on dental silk may not be so bizarre after all.
The post-dental dental thread could be the future of vaccines that appeared first on vice.
