What is nerandomilast (Jascayd)?

Nerandomilast (Jascayd) is a new oral medication used to treat adults with idiopathic pulmonary fibrosis (IPF). The U.S. Food and Drug Administration (FDA) approved nerandomilast in 2025. It is the first new treatment for IPF in more than a decade. causes scarring of the lungs. The damage gets worse over time and it is difficult to catch your breath. As IPF progresses, it becomes difficult to breathe, even at rest.e60dc2a1-f33c-4a05-9b50-8e3e8e597629067b5692-5e0d-45eb-b174-9af21579168c Nerandomilast belongs to a class of drugs called phosphodiesterase 4B (PDE4B). inhibitors. It helps slow the decline of lung function in IPF. This may help people with IPF feel better for longer. Function Nerandomilast works by blocking the PDE4B enzyme. When PDE4B is overactive, it can cause inflammation and tissue damage. Targeting the PDE4B enzyme helps slow lung scarring. pill. This means the medicine made their lungs work better over time. Although it does not cure IPF, nerandomilast may delay its progression.e60dc2a1-f33c-4a05-9b50-8e3e8e5976291e9d8cbd-47a6-42e9-bf4c-ed29548ef050 What are the possible side effects of nerandomilast? Side effects Like most medications, nerandomilast can cause side effects. The most commonly reported problems are: e60dc2a1-f33c-4a05-9b50-8e3e8e597629ffe6e5ee-97b1-40d6-93fb-538a5899d028 Diarrhea Weight loss Headaches COVID-19 Lack of appetite Vomiting Nausea Upper respiratory infection Back pain Fatigue Dizziness Depression Are there any problems Risks associated with nerandomilast? Risks In clinical trials, nerandomilast was found to be safe and well tolerated. liver problems. Also tell your doctor if you: are pregnant planning to become pregnant are breast-feeding are considering breast-feeding It is not known whether nerandomilast can harm a fetus or pass into breast milk. Some data suggests the drug could cause miscarriage. Nerandomilast is intended for adults. Doctors don’t know if it’s safe or effective in children. This medicine may affect the way other medicines work. Tell your doctor about all prescription, nonprescription, recreational (including illegal), herbal, nutritional, or diet medications you take while using nerandomilast. Your doctor may need to adjust your dosage if you are also taking medicines called CYP3A inhibitors or CYP3A inducers. If you take too much nerandomilast, call your doctor or the Poison Control Center at 800-222-1222, or go to the nearest emergency room immediately. Nerandomilast? How to take nerandomilast comes in tablet form to be taken orally. You can take this medicine with or without food. If you are unable to swallow the tablet, you can mix it with water and drink it. Carefully follow the instructions on your package label. The recommended dosage is 18 milligrams (mg) approximately every 12 hours. Your doctor may reduce your dose if you experience side effects. If you miss a dose of nerandomilast, skip it and take your next dose at the scheduled time. Do not double doses.e60dc2a1-f33c-4a05-9b50-8e3e8e5976294e14020c-58aa-47ad-b0bc-9c4e7058e3e0 Take-home Nerandomilast is the first new treatment approved for IPF in more than 10 years. The medication does not cure IPF, but it can slow its progression. In general, nerandomilast causes mild side effects, with diarrhea being the most common. Always discuss all medications you take with your doctor.